Post-doc Researcher in Computational Modeling of Bacterial Efflux Pumps involved in Multi-Drug Resistance.
A post-doc position on timely problems related to multi-drug bacterial resistance mediated by efflux systems is open in our group. The project is funded by the NIAID/NIH grant "Optimization of efflux avoidance and inhibition for antibiotic development" (PI Helen Zgurskaya, University of Oklahoma - USA).
The position is for one year, with a possible extension for a second year.
Tasks:
- MD simulations with standard and enhanced-sampling techniques to investigate the interaction of antimicrobial compounds with bacterial efflux pumps.
- Evaluation of thermodynamics and kinetics associated with molecular recognition and extrusion of compounds and inhibitors by efflux pumps.
- Interactions with all research partners within a multidisciplinary project.
Requirements:
- PhD in Physics, Chemistry, Bioinformatics, Computational biology, Pharmaceutical Chemistry, Biotechnology.
- Strong publication record in the field of molecular simulation/molecular modelling.
- Experience in common molecular modelling/simulation/docking packages.
- Fluent written and spoken English.
- Desirable: experience in QM methods, bioinformatics tools and hybrid QM/MM codes.
For further information please contact:
Prof. Paolo Ruggerone - paolo.ruggerone@dsf.unica.it
People involved:
Dr. Attilio Vittorio Vargiu - attilio.vargiu@dsf.unica.it
Dr. Giuliano Malloci - giuliano.malloci@dsf.unica.it
All documents and instructions needed to apply are available at:
https://pica.cineca.it/unica/27a-2021
Although not explicitly requested in the call, two reference letters are welcome.
Deadline: May 11, 2021